Genesis Mission

NLR supports Genesis Mission—a national initiative to build a powerful scientific platform to accelerate discovery science, strengthen national security, and drive energy innovation through artificial intelligence (AI).

The U.S. Department of Energy's (DOE's) Genesis Mission leverages NLR's ongoing AI and computing efforts to advance real-time energy systems innovation and optimization. Through this initiative, NLR experts and capabilities will contribute to a powerful, integrated scientific platform to advance the nation's technological leadership. Genesis Mission aspires to bring AI beyond standard language generation and software coding into the world of scientific discovery through the scientific datasets and expertise housed in the national labs. This will make science faster, more reliable, and more predictive by embedding Al directly into the machinery of discovery.

Genesis Mission Platform

NLR is an infrastructure partner for the American Science Cloud (AmSC). AmSC is a secure, federated, and science-optimized cloud environment that integrates DOE's world-leading computing and experimental facilities, massive scientific datasets and data resources, and high-performance networks into the world's most powerful integrated scientific platform: the Genesis Mission platform.

AmSC enables DOE scientists to create, access, and integrate world-class AI-ready datasets, run scalable model training on leadership-class systems, perform distributed simulations, control instruments, and move data efficiently across sites.

Artificial Intelligence Model Teams

Genesis Mission is driven by national missions—fusion energy, grid resilience, nuclear stewardship, advanced materials, and more—with success measured in scientific breakthroughs. NLR is participating in multiple AI model teams that are tackling key national challenges. The 27 Genesis Mission national challenges are high-impact, technically ambitious challenges that serve as guiding themes for Genesis and broader national science missions.

Led by NLR, research and capabilities are supporting development of trustworthy, AI-driven systems that can help grid operators and utilities enhance grid operations. In close coordination with other national laboratories, NLR is exploring grid challenges in severe weather and other abnormal conditions and demonstrating how AI can help the grid recover faster from disruptions.

One of the key aspects of the GridAI platform will be the use of privacy preserving federated learning to train and validate foundational models. Privacy preserving federated learning allows for models to learn without sharing sensitive data by training models on proprietary data at the data locations, then sharing the trained model without actually needing to share the data. This will be critical when working with utility and industry partners to develop better AI models.

NLR is using AI to help scale up materials and processes by integrating manufacturing constraints—cost, scale, and supply chain—directly into the discovery phase. This approach can help accelerate the scale-up process and get new materials on the market.

Upon its completion in 2027, NLR's Energy Materials and Processing at Scale facility will serve as a strategic bridge between traditional research and development methods and AI-driven manufacturing, generating real-world data to fuel the digital Genesis Mission platform.

NLR researchers are contributing core AI and modeling capabilities to support end-to-end foundation models, supply chain network analysis, hydrological modeling, and material discovery. This includes developing a dynamic platform that integrates resource discovery, process design, materials discovery, and supply chain analysis. This AI-enabled platform will aim to optimize critical minerals and materials processes and promote a more resilient supply chain for the United States.

About the Initiative

The goal of DOE's Genesis Mission is to develop an integrated platform that connects our nation's best supercomputers, experimental facilities, AI systems, and unique datasets across every major scientific domain to double the productivity and impact of American research and innovation within a decade. By combining the efforts of all 17 national laboratories and pairing researchers with advanced AI tools and computational infrastructure, this platform aims to advance AI and accelerate scientific discovery, drive energy innovation, and strengthen national security.

Contact

Ray Grout

[email protected]